CYP3A7 allele nomenclature

Allele

Protein__

Nucleotide changes

Effect

Enzyme activity

References________

cDNA

Gene

In_vivo

In_vitro

CYP3A7*1A

CYP3A7.1 and CYP3A7.1L

None

None

 

Normal

Normal

Komoti et al, 1989
Rodriguez-Antona et al., 2005

CYP3A7*1B

CYP3A7.1

-314C>T

-314C>T

 

 

 

Kuehl et al, 2001

CYP3A7*1C

CYP3A7.1

-291G>T; -284T>A; -282T>C;
-281A>T; -270T>G; -262T>A;
-232A>C

-291G>T; -284T>A; -282T>C;
-281A>T; -270T>G; -262T>A;
-232A>C

 

 

 Incr.

Kuehl et al, 2001  
Sim et al., 2005

CYP3A7*1D

CYP3A7.1

-91G>A

-91G>A

 

 

 

Kuehl et al, 2001

CYP3A7*1E

CYP3A7.1

-49G>A

-49G>A

 

 

 

Kuehl et al, 2001

CYP3A7*2

CYP3A7.2

1226C>G

26041C>G

T409R

 

Incr.

Rodríguez-Antona et al., 2005

CYP3A7*3

CYP3A7.3

141_142insT

4011_4012insT

48Frameshift

 

 

Shin et al., manuscript in preparation

Changes made since the last update (13-Nov-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

OMIM GeneCards

 

 


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 This page was updated 10-Dec-2007 by Sarah C Sim
Questions and comments are always welcome