CYP2J2 allele nomenclature

Allele

Protein

Nucleotide changes

Effect

Enzyme activity

References

cDNA

Gene

In_vivo

In_vitro

CYP2J2*1

CYP2J2.1

None

None

 

Normal

Normal

 

CYP2J2*2

CYP2J2.2

427A>G

14488A>G

T143A

 

Reduced AA and LA metabolism 

King et al., 2002

CYP2J2*3

CYP2J2.3

472C>T

14533C>T

R158C

  

Reduced AA and LA metabolism 

King et al., 2002

CYP2J2*4

CYP2J2.4

575T>A

15029T>A

I192N

  

Reduced AA metabolism 

King et al., 2002

CYP2J2*5

CYP2J2.5

1024G>A

21709G>A

D342N

  

Normal metabolism of AA and LA 

King et al., 2002

CYP2J2*6

CYP2J2.6

1210A>T

25662A>T

N404Y

  

Reduced AA and LA metabolism

King et al., 2002

CYP2J2*7

CYP2J2.7

 

-76G>T

 

Decr.

Reduced transcription due to loss of Sp1 binding site

King et al., 2002
Spiecker et al., 2004

CYP2J2*8

CYP2J2.8

934G>A

18892G>A

G312R

 

 

Shin et al., 2005

CYP2J2*9

CYP2J2.9

1052C>T

21737C>T

P351L

 

 

Shin et al., 2005

CYP2J2*10

CYP2J2.10

344C>T

10780C>T

P115L

 

 

Gaedigk et al., 2006

AA, arachidonic acid; LA, linoleic acid

Changes made since the last update (27-Mar-2007) are marked in red.

Links to the NCBI dbSNP homepage are available for functional SNPs when present in NCBI's database.

Nucleotide variations in bold are the major SNPs/alterations responsible for the phenotype of the corresponding allele.

OMIM GeneCards

 

 


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CYP2R1 CYP2S1 CYP2W1 CYP3A4 CYP3A5 CYP3A7 CYP3A43 CYP4A11 CYP4A22 CYP4B1 CYP4F2 CYP5A1 CYP8A1 CYP19A1 CYP21A2 CYP26A1 POR

This page was updated 13-Nov-2007 by Sarah C Sim
Questions and comments are always welcome